Immunohistochemical and ultrastructural study of Sertoli cells in androgen insensitivity

Complete Androgen Insensitivity Syndrome in Three Sisters

Sertoli cell nodules in the undescended testis: a histochemical, immunohistochemical, and ultrastructural study of hyaline deposits.

AIMS To document the morphology, immunohistochemical staining properties, and ultrastructural features of hyaline material in Sertoli cell nodules of undescended testis and contrast them with those of sex cord tumour with annular tubules (SCTAT), which is histologically similar. To highlight the need to distinguish these nodules from other Sertoli cell hyperplasias, such as intratubular Sertoli...

The Ultrastructural Changes of the Sertoli and Leydig Cells Following Streptozotocin Induced Diabetes

Objective(s) This investigation was conducted to evaluate the effects of diabetes on the structure and function of testicular tissue. Materials and Methods Diabetes was induced in male adult rats by a single intraperitoneal injection of streptozotocin. Body and testicular weight, hormonal analyses, histological and ultrastructural analyses were measured. Results The body and testicular we...

Androgen-Responsive MicroRNAs in Mouse Sertoli Cells

Although decades of research have established that androgen is essential for spermatogenesis, androgen's mechanism of action remains elusive. This is in part because only a few androgen-responsive genes have been definitively identified in the testis. Here, we propose that microRNAs--small, non-coding RNAs--are one class of androgen-regulated trans-acting factors in the testis. Specifically, by...

P-48: Ultrastructural and L.Microscopic Study of GnRH Potential in Inhibition of Side Effect of Drugs Used In Chemoterapy on Sertoli Cells

Background: Male factors, mainly spermatogenesis disorder, are responsible for 20 – 30% of infertility ocuurs in different societies. One of the known causes of spermatogenesis disorder is chemotherapy in patients with cancer. The side effect of chemoterpic agents may last from 10 years up to the end of the life. Since dividing cells are mainly affected by anticancer drugs, the aim of the prese...